Advance in research for afatinib and its analogues, the multi-target tyrosine kinase inhibitor / 中国药学杂志

ABSTRACT

OBJECTIVE: To review the lastest research progress afatinih and its analogues, which are multi-target tyrosine kinase inhibitor. METHODS: By consulting references, the synthesis afatinib, the design, synthesis and antitumor activity its analogues are summarized, the antitumor activity, structure-activity relationship, pharmacokinetic research, adverse reaction are also summarized. RESULTS: The research progress afatinib and its analogues was comprehensively summarized. CONCLUSION: Although afatinib has much adverse reaction, it still has a good prospect and its analogues may be worth further studying.