Fast determination of coating thickness of the total saponin of Radix Bupleuri enteric coated tablets by MRS / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 2128-2133, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-860115
ABSTRACT
OBJECTIVE:
To establish a rapid and nondestructive method to determine coating thickness of the total saponin of Radix Bupleuri enteric coated tablets by near infrared spectroscopy (NIRS) analytical technique.METHODS:
Spectral pretreating methods, wavenumber selection and factors of NIRS were discussed in detail. Different modeling methods were compared and the methodology of model was investigated.RESULTS:
Partial least squares regression (PLSR) was used for building the quantitative calibration model. Correlation coefficients(r), root-mean-squares error of cross-validation (RMSECV), and root mean square error of prediction (RMSEP) obtained by PLSR model were 0.9915, 3.6 and 3.24 μm respectively.CONCLUSION:
Predicted results show that the established method is rapid, nondestructive, and reliable, which can be applied to the online monitor of Chinese medicine tablets coating process.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2014
Tipo del documento:
Artículo
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