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Mixed terpenoids from an endophyte Alternaria sp. Ly81 cultivated on Maytenus hookeri / 中国药学杂志
Chinese Pharmaceutical Journal ; (24): 1823-1826, 2014.
Artículo en Chino | WPRIM | ID: wpr-860151
ABSTRACT

OBJECTIVE:

To study the secondary metabolites and their cytotoxic activities of an endophytic fungus Alternaria sp. Ly81 cultivated on Maytenus hookeri.

METHODS:

Column chromatography by RP-18, Sephadex LH - 20 and silica gel was used to isolate and purify the chemical constituents, and their structures were identified by spectroscopic analysis. Cytotoxic activities were evaluated by MTT method.

RESULTS:

Nine compounds were isolated and identified as tricycloalternarene 2a(1), tricycloalternarene 1a(2), tricycloalternarene 1b(3), tricycloalternarene 2b(4), tricycloalternarene 3b(5), tricycloalternarene 4b(6), tricycloalternarene 5b(7), tricycloalternarene-H(8) and tricycloalternarene F(9).

CONCLUSION:

Compounds 1 - 9 were isolated from the Alternaria sp. Ly81 for the first time. The absolute configuration of compound 1 is elucidated by Mosher's method. Compound 3 shows strong inhibitory activity against Lewis lung carcinoma cells 3LL.

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Pharmaceutical Journal Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Idioma: Chino Revista: Chinese Pharmaceutical Journal Año: 2014 Tipo del documento: Artículo