Research progress in influence factors of excretion delay of high-dose methotrexate / 中国药学杂志

ABSTRACT

OBJECTIVE: In order to make a more rational clinical use of methotrexate and reduce adverse reactions, we summarize the factors that might cause excretion delay of high-dose methotrexate. METHODS: After consulting relevant domestic and overseas documents published recently, we summed up some factors that might cause excretion delay of high-dose methotrexate. RESULTS AND CONCLUSION: Physiological states of patients, drug interactions, drug-metabolizing enzymes, and many other factors all may lead to excretion delay of methotrexate. Therefore, we should pay attention to these factors to reduce the incidence of excretion delay and ensure safe medication in clinical application of methotrexate.