Secondary metabolites from endophyte fungus Fusariums sp. LC-1 / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the chemical constituents of the endophyte fungus Fusariums sp. LC-1. METHODS: The compounds were isolated from the ethyl acetate extract and acetone extract by silica gel column chromatography, Sephadex LH-20 column chromatography and HPLC techniques. And their structures were identified by the physicochemical properties and spectral analysis. RESULTS: Seventeen compounds were obtained from the static liquid culture of endophyte fungus Fusariums sp. LC-1. They were identified as cyclo(Gly-Val) (1), cyclo (Gly-Ile) (2), beauvericin (3), ergosterol (4), 3β, 5α, 6β, 9α-tetrahydroxyergosta-7, 22-diene (5), fusaric acid (6), dehydrofusaric acid (7), p-hydroxybenzoic acid (8), cyclo (Hyp-Leu) (9), cyclo (Gly-Pro) (10), cyclo (Ala-Phe) (11), cyclo(Leu-Ala) (12), cyclo(Leu-Val) (13), cyclo(Phe-Gly) (14), cyclo-(Leu-Gly) (15), uracil (16) and thymine (17). CONCLUSION: Compounds 1 and 2 are isolated from natural material for the first time. Compounds 5, 9, 12, 13 and 14 are isolated from endophyte fungus Fusariums sp. for the first time. Copyright 2013 by the Chinese Pharmaceutical Association.