Anti-inflammatory and the analgesic effects of Compound matrine and baicalin ointment / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the analgesic and anti-inflammatory effects of Compound matrine and baicalin ointment traditional Chinese medicines. METHODS: The analgesic action was observed by mice hot-board and acetic-acid-induced twisting experiments. The swelling of ear induced by xylene and the increase of capillary permeability by acetic acid in mice were used to explore the anti-inflammatory effects. RESULTS: Compound matrine and baicalin ointment could significantly inhibit the inflammation of auricle. Compared with the group 1 (negative control group), there was significant difference (P 0.05). While comparing the effects between the mice in the group 1 and group 4 (matrix group), there was no difference (P > 0.05). Compound matrine and baicalin ointment also had good anti-inflammatory effect on the inflammation caused by intraperitoneal injection of acetic acid which could increase capillary permeability of mice. It could obviously elevate the threshold of pain in the hot-plate procedure and inhibit twisting reaction induced by acetic acid in mice. Compared with group 1, the differences were significant (P 0.05). And Compound matrine and baicalin ointment also has a good analgesic action to inhibit twisting reaction induced by acetic acid in mice. Compared with group 1 and group 4, the differences were significant (P 0.05). CONCLUSION: Compound matrine and baicalin ointment has anti-inflammatory and analgesic effects in mice.