Drug release property of modified hyaluronic acid films in vitro / 中国药学杂志

ABSTRACT

OBJECTIVE: To evaluate the in vitro drug release properties of modified hyaluronic acid films. METHODS: The drug release rates of the films were measured by dictyo-dish method and UV-Vis absorption spectroscopy. The effects of modifier contents and the solubility of medicines on the release were investigated. RESULTS: The release of some hydrophobic drugs from the films were sustained. The drug release pattern followed Higuchi equation, and was controlled by diffusion mechanism. Drug release rates were delayed by increasing contents of modifier. CONCLUSION: The films made of modified hyaluronic acid have excellent potentials as carriers for the sustained release of some hydrophobic drugs. Copyright 2012 by the Chinese Pharmaceutical Association.