Pharmacokinetics of dexibuprofen in rats after oral administration of dexibuprofen and dexibuprofen arginate / 中国药学杂志

ABSTRACT

OBJECTIVE: To establish an HPLC-MS/MS method for the determination of dexibuprofen in rat plasma and to study the pharmacokinetic profiles of dexibuprofen in rats after oral administration of dexibuprofen suspention or dexibuprofen arginate aqueous solution. METHODS: Dexibuprofen suspention or dexibuprofen arginate aqueous solution was administered orally as a single dose to rats. Blood was collected at different time points and blood samples were prepared by protein precipitation. The concentration of dexibuprofen in plasma was determined by an HPLC-MS/MS method using indomethacin as internal standard. RESULTS: The oral administration of both dexibuprofen suspention and dexibuprofen arginate aqueous solution resulted in rapid absorption of dexibuprofen. The AUC of dexibuprofen after oral administration of dexibuprofen arginate aqueous solution in rats was significantly higher than the ALC of dexibuprofen after administration of dexibuprofen suspention at equivalent dose. CONCLUSION: Dexibuprofen will show an enhancement in oral bioavailability in the salt formulation as dexibuprofen arginate. Copyright 2012 by the Chinese Pharmaceutical Association.