An evidence-based evaluation of efficacy of Marvelon combined with metformin for polycystic ovary syndrome / 中国药学杂志

ABSTRACT

OBJECTIVE: To evaluate the efficacy of Marvelon combined with metformin in the treatment of polycystic ovary syndrome(PCOS). METHODS: Both prospective and retrospective clinical studies on the efficacy of Marvelon combined with metformin were searched in several databases of medicine and pharmacy, and the data was analyzed by evidence-based literature analysis method. RESULTS: There were nine randomized controlled trials(RCTs) in Chinese on Marvelon combined with metformin for the treatment of PCOS. Marvelon combined with metformin could improve hormone levels, promote ovulation and pregnancy rate markedly. CONCLUSION: It has been demonstrated in the researches that Marvelon combined with metformin is more effective for polycystic ovary syndrome(PCOS), however, further randomized, double-blind studies with larger sample size are needed to prove the efficacy and safety of Marvelon combined with metformin.