Extraction optimization of anthraquinone from aerial part of Rheum officinale Baill based on Plackett-Burman design combined with CCD response surface methodology / 中国药学杂志
Chinese Pharmaceutical Journal
;
(24): 410-414, 2012.
Artículo
en Chino
| WPRIM
| ID: wpr-860782
ABSTRACT
OBJECTIVE:
To optimize the process of extacting effective constituents from aerial part of Rheum officinale Baill by Plackett-Burman design combined with CCD response surface methodology.METHODS:
In Plackett-Burman combined with CCD response surface design, the independent variables were concentration of ethanol, extraction time, and solvent fold. The dependent variables were contents of total anthraquinone and rheum emodin.RESULTS:
The optimal extraction process of total anthraquinone was as follows 67.25% ethanol, 90 min for reflux per time, 281 fold of solvent and 2 times of extraction; the optimal extraction process of emodin was 85% ethanol, 90 min for reflux per time, 40 fold of solvent and 2 times of extration.CONCLUSION:
The optimal process is simpleand convenient for extracting aerial part of Rheum officinale Baill with high precision and predictability. Copyright 2012 by the Chinese Pharmaceutical Association.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Pharmaceutical Journal
Año:
2012
Tipo del documento:
Artículo
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