Simultaneous determination of 238 pesticide residues in Astrgalus membranaceus by GC-MS/MS / 中国药学杂志

ABSTRACT

OBJECTIVE: To study the multi-residues detection methods for Astrgalus membranaceus by GC-MS/MS. METHODS: The extraction was performed by modified QuEChERS method, and then cleaned by PSA solid phase extraction (SPE) cartridge. The residue detection was carried out by GC-MS/MS, which could identify and quantify pesticide simultaneously. RESULTS: The analytical performance was validated by recovery experiments that were fortified at three levels for each pesticide. In general, the recoveries ranged from 70% to 120% and the relative standard deviations (RSDs) were all less than 15%. The limits of detection (LODs) for most of the selected pesticides were below 0.01 mg · kg-1. CONCLUSION: The method shows high sensitivity, good repeatability and satisfactory cleaning-up excellence, which could be applied to the pesticide residue detection for Astrgalus Membranaceus. Copyright 2012 by the Chinese Pharmaceutical Association.