Observation on vulnerable coronary plaques in HIV-infected patients based on coronary CTA / 中国医学影像技术

ABSTRACT

Objective: To explore whether vulnerable coronary plaques in HIV-infected patients are different with those in non-HIV-infected ones, and to analyze the relative risk factors. Methods: A total of 167 HIV-infected patients (HIV-infected group) and 185 non-HIV-infected patients(non-HIV-infected group) who underwent coronary CTA (CCTA) were collected. Vulnerable plaques were defined as those with two or more high-risk morphological features. The type, location and incidence of vulnerable coronary plaques were analyzed and compared between 2 groups, and the risk factors of vulnerable coronary plaques in HIV-infected patients were analyzed. Results: There was no significant difference of baseline clinical data between the two groups. The most common types of vulnerable coronary plaques in 2 groups were both low attenuation plaques+positive remodeling, most located in the proximal segment of left anterior descending artery (segment 6). The incidence of vulnerable coronary plaques ≥1 coronary segments in HIV-infected patients was higher than that in non-HIV-infected patients (34.73% vs 24.32%,P<0.05). Vulnerable coronary plaques in HIV-infected patients were independently correlated with the duration of antiretroviral therapy (ART) drug (OR=1.29, 95%CI [1.04,1.59], P=0.02). Conclusion: The incidence of vulnerable coronary plaques in HIV-infected patients was higher than that in non-HIV-infected patients. ART drug may be an independent risk factor for coronary plaque vulnerability in HIV-infected patients.