Impact of iodinated contrast agents on blood oxygenation level of renal in rabbits with diabetic nephropathy using BOLD-MRI / 中国医学影像技术

ABSTRACT

Objective: To evaluate the impact of iodinated contrast media on renal oxygenation content in rabbits with diabetic nephropathy using BOLD-MRI. Methods: Totally 32 rabbits with diabetic nephropathy (experimental group) were randomly divided into 4 groups (each n=8) and received iodinated contrast media with different concentration (200, 240, 300, 350 mgI/ml, named 200 subgroup, 240 subgroup, 300 subgroup and 350 subgroup, respectively). Rabbits in control group (8 normal rabbits) received normal saline (NS). BOLD-MRI was performed at 1, 24, 48 and 72 h after injection, and R2* value of renal cortex, extramedulla and intramedulla of the rabbits were measured and compared among different groups and different time points. Results: One hour after administration of iodinated contrast media, R2* value of the renal cortex, extramedulla and intramedulla increased in experimental group, reaching their peak value at 24 h and then declined. Significant differences of R2* value were found among 4 subgroups at all time points after injection (all P<0.001), and with the increase of iodine concentration, R2* value increased, with the highest R2* value observed in 350 subgroup. In experimental group, R2* value of the extramedulla was higher than the cortex and intramedulla 24 h after injection in 350 subgroup (both P<0.05). Conclusion: Iodinated contrast media can significantly affect the oxygen content of renal extramedulla in diabetic nephropathy rabbits, and the changes may have certain rules. BOLD-MRI can provide auxiliary information for rational clinical application of contrast agent and monitoring renal function.