Dynamic contrast-enhanced MRI and 1H-MRS in diagnosis of breast cancer: Meta-analysis / 中国医学影像技术

ABSTRACT

Objective: To observe the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI), 1H-MRS and the combination of them for breast cancer using Meta-analysis. Methods Literatures from PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP databases were searched from establishment to May 2018, for the diagnostic studies about breast cancer by DCE-MRI, 1H-MRS and the combination of these two methods. Meta-Disc 1.4 and STATA 12.0 software were used for Meta-analysis. Results Totally 14 studies were enrolled. The pooled sensitivity of DCE-MRI, 1H-MRS and the combination of these two methods in diagnosing breast cancer was 0.93 (95%CI [0.90, 0.95]), 0.80 (95%CI [0.76, 0.83]) and 0.95 (95%CI [0.92, 0.97]), the pooled specificity was 0.77 (95%CI [0.73, 0.82]), 0.81 (95%CI [0.77, 0.85]) and 0.83 (95%CI [0.77, 0.87]), the pooled diagnostic odds ratio was 43.69 (95%CI [28.38, 67.26]), 24.24 (95%CI [16.24, 36.16]) and 95.64 (95%CI [48.90, 187.07]), the AUC of summary receiver operating characteristic curve was 0.932 9, 0.899 9 and 0.961 9, respectively. Conclusion DCE-MRI and 1H-MRS are both effective diagnostic technique for breast cancer, and the combination of these two methods can provide more preferable diagnostic accuracy than single use of them.