Application of Probiotics Combined With Soluble Dietary Fiber in Middle-aged and Elderly Patients With Chronic Constipation / 胃肠病学

ABSTRACT

Background: Chronic constipation (CC) is one of the most common problems affecting quality of life in elderly people. Probiotics, dietary fiber are important means for CC treatment. Aims: To explore the effect of probiotics combined with soluble dietary fiber in middle-aged and elderly patients with CC. Methods: A total of 180 middle-aged and elderly patients with CC were enrolled and randomly divided into control group, probiotics group, dietary fiber group and probiotics combined with dietary fiber group. Patients in control group were implemented with normal health education, patients in the other three groups were given Entrocoordinatibiogen, soluble dietary fiber and probiotics granules combined with dietary fiber, respectively. After 2 weeks treatment, defecation frequency, diversity of fecal bacteria flora, score of patient assessment of constipation symptom (PAC-SYM) and patient assessment of constipation quality of life (PAC-QOL) were observed. Results: After 2 weeks treatment, there were statistically significant differences in defecation frequency, diversity of fecal bacteria flora, PAC-SYM score, PAC-QOL score and overall effective rate among control group, probiotics group, dietary fiber group and combination group (P<0.05). The above-mentioned indices in three treatment groups were significantly improved when compared with control group (P<0.05). Conclusions: Probiotics and soluble dietary fiber could increase the diversity of enteric fecal bacteria flora, relieve constipation symptoms effectively and improve life quality of CC patients.