Progress of clonal hematopoiesis and its relationship with hematological malignancies / 白血病·淋巴瘤

ABSTRACT

With the application of high-throughput gene sequencing, a proportion of somatic gene mutations and clonal hematopoiesis has been found in cases with idiopathic cytopenia of undetermined significance, aplastic anemia, and even in the blood cells of healthy adults. Further researches also put forward concepts such as clonal hematopoiesis of indeterminate significance, clonal cytopenia of undetermined significance, clonal hematopoiesis with oncogenic potential. Studies also showed that clonal hematopoiesis is closely related to inflammation, cardiovascular diseases, solid tumors, and treatment-related bone marrow neoplasms. This article introduces the research progress of clonal hematopoiesis and its relationship with hematological malignancies in combination with the reports at the 61st American Society of Hematology Annual Meeting.