Advances of epigenetic mechanism of tetralogy of Fallot / 国际儿科学杂志

ABSTRACT

Epigenetics refers to the heritable changes of gene expression without altering DNA sequence.Epigentic mechanism involves DNA methylation,microRNA,histone modification and so on.Tetralogy of Fallot (TOF) is a common congenital heart disease characterized by ventricular septal defect,pulmonary stenosis,aortic straddling and right ventricular hypertrophy.Many experimental investigations indicate that epigentics plays an important role in the development of the heart.It will be an important research field in the future showing important clinical significance to study the etiology of tetralogy of Fallot.