Screening infant spasmodic differentially expressed protein based on iTRAQ technique / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 213-216, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-862956
ABSTRACT
Objective:
To screen serum biomarkers of infantile spasm by iTRAQ technique.Methods:
Fifteen cases of infants with infantile spasm and 15 cases of healthy infants were selected to find the plasma differential proteins by isobaric tag for relative and absolute quantitation(iTRAQ) technique and analysis of the biological information, then candidate proteins with significant differences were screened out.Results:
Compared with the control group, 59 different proteins were obtained in the experimental group with a multiple of 1.2 times, which were involved in biological processes such as cytoskeleton organization, integrin activation and maintenance of protein location in cells.Five disease-related protein markers were selected and discussed.Conclusion:
Differences in protein expression were found in plasma between infants with infantile spasm and normal controls.It may provide a new direction for the research of infant spasm.The research of cytoskeleton protein may become the breach of the infant spasm pathogenesis.New potential biomarkers, such as serine/threonine protein kinase and dopamine beta hydroxylase may provide a new direction for diagnosis and treatment of infant spasm.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Idioma:
Chino
Revista:
International Journal of Pediatrics
Año:
2020
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS