Progress in the pathogenesis of Henoch-Sch?nlein purpura nephritis and IgA nephropathy in children / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 569-572, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-863021
ABSTRACT
Henoch-Sch?nlein purpura nephritis and IgA nephropathy are both characterized by extensive deposition of IgA in the mesangial area.In recent years, the researches on the pathogenesis of the two diseases have made significant progress.It was confirmed that the pathogenesis included the aberrantly glycosylated IgA1, abnormal complement activation, cellular immune imbalance and cytokine production disorder, genetic factors and so on.Furthmore, some other immunopathogenic mechanisms have a breakthrough on endothelial cell particles, extracellular trapping nets, podocyte autophagy and abnormal peptide lineage, offering new ideas for diagnosis and treatment of disease.This paper will review the above pathogenesis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio de etiología
Idioma:
Chino
Revista:
International Journal of Pediatrics
Año:
2020
Tipo del documento:
Artículo
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