Diagnosis and treatment of sepsis associated disseminated intravascular coagulation in children / 国际儿科学杂志

ABSTRACT

Sepsis associated disseminated intravascular coagulation is a common complication of sepsis and one of the major causes of increased mortality in pediatric intensive care units.When sepsis occurs, the inflammatory factor storm will cause damage to various tissues and organs of the body, and its complication DIC will further aggravate the organ dysfunction.Therefore, the early detection of DIC is crucial in the treatment of sepsis in children.Since the first diagnostic criteria were proposed by the ministry of health and welfare of Japan (JMHW) in 1983, new diagnostic criteria have been proposed in recent years.At the same time, timely diagnosis is helpful for early intervention to improve the prognosis, so a variety of treatment schemes have also emerged.This article reviews the establishing history, advantages and disadvantages of the diagnostic criteria for sepsis associated DIC, as well as the research progress on various anticoagulants and anticoagulant therapies.