Treatment of intrahepatic cholangiocarcinoma based on biological behavior / 国际外科学杂志

ABSTRACT

Intrahepatic cholangiocarcinomas (ICC) arise above the second order bile ducts, has a unique biological characteristics. Liver resection is the most effective treatment. Minimally invasive surgery, associating liver partition and portal vein ligation for staged hepatectomy, regional lymphadenectomy and liver transplantation are the main advancement of surgical treatment in ICC. Traditional CT and laboratory markers are incorporated to predict long-term outcomes after resection for ICC. Adjuvant chemotherapy and neoadjuvant therapies are proved to be the optimal treatment in selected patients. A lot of targetable mutations have been comprehensively characterised and clinical data is emerging on targeting these oncogenic drivers. Also, the role of immunotherapy has been examined and is an area of intense investigation. Herein, a deeper understanding of the molecular and genomic pathogenesis of this entity has led to several advances in the individualized treatment of ICC.