Clinical characteristics and treatment changing of pyogenic liver abscess / 国际外科学杂志

ABSTRACT

Pyogenic liver abscess(PLC) is a common infectious disease in the hepatobiliary system. For people with high risk factors such as diabetes mellitus and cardiovascular diseases, the presence of this disease should be warned when clinical manifestations including fever and abdominal pain occur. In recent years, great changes were observed in the characteristics, high risk factors, pathogenic bacteria and treatment strategy of PLC. The most common pathogens of liver abscess are so-called Gram-negative bacteria such as Escherichia coli and Klebsiella pneumoniae and Klebsiella. pneumoniae has replaced Escherichia coli as the most common microorganism isolated from PLA infections. As liver abscesses caused by Klebsiella. pneumoniae can produce invasion syndromes, including endophthalmitis, central nervous system infection, other extrahepatic infections. The most common laboratory abnormality among included items was increased C-reactive protein and white blood cell levels. Pyogenic liver abscess can be diagnosed differently via ultrasound or CT scan from other liver lesions. Once recognized, percutaneous drainage guided by ultrasound and CT and antibiotic treatment are the mainstay of management for PLA. The aim of this article is to review clinical characteristics and treatment changing in recent years.