Clinical study on Qingjin-Huatan Decoction combined with western medicine in the treatment of acute aggravation of bronchiectasis / 国际中医中药杂志

ABSTRACT

Objective:To evaluate the clinical effect of Qingjin-Huatan Decoction combined with conventional western medicine in the treatment of acute aggravation of bronchiectasis. Methods:A total of 80 patients in Beijing Sixth Hospital from January 2014 to December 2018 were included. Patients were divided into two groups according to random number table method, 40 cases in each group. The control group was treated with conventional western medicine. The research group was treated with Qingjin-Huatan Decoction based on the control group. Both of the two groups were treated continuously for 7 days. Before and after the treatment, their symptoms and signs were scored, forced expiratory volume in one second (FEV1), forced vital capacity (FVC) and peak expiratory flow (PEF) were detected by pulmonary function tester, serum neutrophil elastase (NE) and cathepsin G were detected by ELISA, tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4) and interleukin-6 (IL-6) in sputum were detected by ELISA, and clinical efficacy was evaluated. Results:The total clinical effective rate of the research group and the control group was 90.0% (36/40) and 77.5% (31/40) respectively. The difference between the two groups was statistically significant ( χ2=4.501, P=0.034). After the treatment, the scores of cough, expectoration, phlegm quality, phlegm quantity, fever, shortness of breath, thirst, chest distress and wet rales in the research group were significantly lower than those of the control group ( t values were 15.240, 16.910, 21.761, 18.949, 16.740, 9.285, 11.732, 9.050, 11.193, all Ps<0.001), FEV1, FVC and PEF were all significantly higher than those of the control group ( t values were 5.085, 4.468 and 4.219, respectively, all Ps<0.001), the levels of TNF-α, IL-4 and IL-6 in sputum were all significantly lower than those of control group ( t values were 8.341, 8.884 and 11.352, respectively, all Ps<0.01), and the levels of serum NE (26.20 ± 3.18 μg/L vs. 51.15 ± 5.24 μg/L, t=25.744) and cathepsin G (5.62 ± 1.01 μg/L vs. 8.05 ± 1.33 μg/L, t=9.203) were significantly lower than those of control group ( P<0.001). Conclusions:The Qingjin-Huatan Decoction combined with conventional western medicine can relieve clinical symptoms of patients with acute aggravation of bronchiectasis, improve pulmonary function, inhibit the expression of inflammatory cytokines and proteolysis activities in the airway, and improve the clinical efficacy.