Etiologic characteristics of adults with community-acquired pneumonia / 中华急诊医学杂志

ABSTRACT

Objective:To investigate the etiologic characteristics of adults with community acquired pneumonia (CAP).Methods:Respiratory tract specimens were collected from 246 cases of community acquired pneumonia in Peking University Third Hospital after excluding tuberculosis, pulmonary tumor, non-infectious pulmonary interstitial disease, pulmonary edema, pulmonary atelectasis, pulmonary embolism, pulmonary eosinophil infiltration and pulmonary vasculitis. Nineteen respiratory pathogens were tested by multiple real-time fluorescent quantitative PCR to investigate the distribution of respiratory pathogens.Results:The positive rate of nucleic acid detection in respiratory pathogens was 46.7%, among which 25.6% was virus, 19.9% atypical pathogens and 18.7% bacteria. The most prevalent viruses were influenza virus (14.6%), parainfluenza virus (2.8%) and rhinovirus (2.8%). The three most prevalent bacteria were Streptococcus pneumoniae (8.5%), Haemophilus influenzae (6.1%)and Klebsiella pneumoniae (2.4%). The positive rate of Mycoplasma pneumoniae was higher in patients <65 years than that in patients≥65 years (21.3% vs 2.6%, χ 2=10.376, P=0.001). Conclusions:Respiratory virus is the leading respiratory pathogens in community acquired pneumonia exceeding bacteria and Mycoplasma pneumoniae, Influenza virus and Streptococcus pneumoniae are the top three pathogens in CAP.