Analysis of diagnosis and treatment of Staphylococcus aureus pneumonia and its extrapulmonary lesions / 中华实用儿科临床杂志

ABSTRACT

Community-acquired pneumonia (CAP) is a leading cause of death in children under 5 years old.Bacterial pneumonia is still the primary cause of severe pneumonia.Prevalence of Staphylococcus aureus CAP and its clinical features remain incompletely understood, complicating the empirical selection of antibiotics. Staphylococcus aureus is the main bacterial pathogen of CAP besides Streptococcus pneumoniae.Due to the virulence its bacterial factors involved in nasal colonization and its relationship with the host immune response, staphylococcus aureus is easy to cause lung damage after the virus infection. Staphylococcus aureus also produces panton-valentine leukocidin, and other toxin factors, which lead to the death of host cells after infection, activate humoral immunity, produce a large number of inflammatory factors, further cause primary and secondary acute lung injury, and may cause systemic collapse infection.At pre-sent, there is little in-death research on the relationship between the toxicity of Staphylococcus aureus and the host immune response.The prevalence of methicillin resistant Staphylococcus aureus makes the anti-infection treatment increa-singly difficult.It is urgent to improve the comprehensive diagnosis and treatment measures, improve the treatment rate, reduce the disability rate, and develop therapies targeted at both pathogen virulence factors and host immunomodulation.