Effect of early intensive intravenous nutrition on growth and immune function of premature infants / 中国医师进修杂志

ABSTRACT

Objective:To explore the effects of early fortified amino acid nutrition on nutritional indicators, development and immune function of premature infants.Methods:From January 2017 to December 2018, 150 premature infants hospitalized in the neonatal intensive care unit of the Second Hospital of Shanxi Medical University were selected. Using random number table method, the children were randomly divided into group A, group B and group C, with 50 cases in each group. Group A was given a total intravenous nutrition strategy within 24 h of birth, group B was given a total intravenous strategy within 48 h of birth, and group C was given a total intravenous strategy within 72 h of birth. The children in the three groups were observed in the hospital until discharged. The levels of liver function, nutritional indicators and immune function were detected in the three groups.Results:The levels of body mass increase rate, head circumference increase rate and body length increase rate in group A were higher than those in group B and group C [22.73 ± 2.02) g/(kg·d) vs. (19.90 ± 1.89) and (17.60 ± 2.01) g/(kg·d), (0.76 ± 0.17) cm/week vs. (0.69 ± 0.18) and (0.60 ± 0.15) cm/week,(1.21 ± 0.20) cm/week vs. (1.02 ± 0.24) and (0.89 ± 0.22) cm/week], and there were significant differences ( P<0.05). After treatment, the levels of alanine aminotransferase, aspartate aminotransferase in three groups had no significant differences ( P>0.05). After treatment, the levels of total albumin and albumin in group A were higher than those in group B and group C [(49.92 ± 3.30) g/L vs. (45.03 ± 2.94) and (42.03 ± 3.00) g/L, (33.10 ± 2.02) g/L vs. (29.89 ± 1.95) and (25.59 ± 2.00) g/L], and there were significant differences( P<0.05). After treatment, the levels of CD 3+ and CD 4+ in group A were higher than those in group B and group C [(68.80 ± 4.01)% vs. (59.02 ± 3.20)% and (55.03 ± 3.10)%,(43.31 ± 2.09)% vs. (38.82 ± 2.06)% and (34.40 ± 2.11)%], the level of CD 8+ in group A was lower than that in group B and group C [(23.30 ± 2.80)% vs. (28.89 ± 2.91)% and (34.40 ± 2.05)%], and there were significant differences ( P<0.05). Conclusions:Early fortified amino acid nutrition can significantly improve the nutritional status and immune function of premature infants, and contribute to their growth and development.