Effect of oxygen-driven aerosol inhalation of anti-asthmatic drugs in the treatment of elderly patients with chronic bronchitis and its influence on the quality of life / 中国基层医药

ABSTRACT

Objective:To investigate the effect of oxygen-driven aerosol inhalation of anti-asthmatic drugs in the treatment of elderly patients with chronic bronchitis and its influence on the quality of life.Methods:From January 2015 to January 2018, 68 elderly patients with chronic bronchitis in Zhejiang Xin'an International Hospital were randomly selected and divided into control group and observation group according to different treatment methods, with 34 cases in each group.The control group was given anti-infective, relieving cough and asthma, ultrasonic atomized inhalation and other treatments, meanwhile oral health education and routine care were also given.The observation group was implemented oxygen-driven aerosol inhalation of anti-asthmatic drugs based on the control group.The phlegm quantity of the two groups was recorded on the 1st, 2nd, 3rd, 4th and 5th day of treatment.The respiratory rate, heart rate and SpO 2 were measured during the treatment period.The improvements of clinical symptoms and signs were compared.The anxiety, depressive symptoms, treatment adherence, subjective well-being and quality of life of the two groups before and after intervention were evaluated. Results:The amount of sputum in the observation group was significantly higher than that in the control group on day 1, 2 and 3[(18.53±2.96)mL vs.(15.42±2.72)mL, (27.69±7.22)mL vs.(21.52±4.58)mL, (36.11±5.24)mL vs.(25.48±4.57)mL] ( t=4.511, 4.208, 8.915, P=0.000, 0.000, 0.000). At the 4th day after treatment, the amount of sputum had no statistically significant difference between the two groups ( t=0.013, P=0.989). At the 5th day after treatment, the amount of sputum in the observation group was significantly less than that in the control group[(26.62±4.47)mL vs.(33.11±8.74)mL]( t=3.855, P=0.000). The respiratory rate and heart rate had no statistically significant differences between the two groups during treatment (all P>0.05). The SpO 2 level in the observation group was significantly lower than that in the control group[(92.00±3.00)% vs.(95.00±2.00)%]( t=4.852, P=0.000). The cough improvement time, dyspnea relief time and the improvement time of lung wet snoring sound in the observation group were significantly shorter than those in the control group[(2.88±0.55)d vs.(3.91±0.74)d, (3.17±0.62)d vs.(3.96±0.75)d, (3.63±0.61)d vs.(4.08±0.76)d]( t=6.514, 4.734, 2.693, P=0.000, 0.000, 0.001). The treatment adherence and quality of life scores of the two groups after intervention were significantly higher than before intervention (control group t=7.226, P=0.000; observation group t=18.073, P=0.000). The scores of treatment adherence and quality of life in the observation group were (93.58±6.25)points and (89.63±9.88)points, which were significantly higher than those in the control group [(82.15±6.33points and (78.93±10.22)points] ( t=7.492, 4.389, P=0.000, 0.000). The subjective well-being scores of the two groups after intervention were significantly lower than before intervention (control group t=10.338, 4.474, P=0.000, 0.000; observation group t=16.354, 8.939, P=0.000, 0.000), the decline of the observation group was more significant compared with the control group ( t=13.936, P=0.000). Conclusion:Oxygen-driven aerosol inhalation of anti-asthmatic drugs has good antispasmodic and antitussive effect in the treatment of elderly patients with chronic bronchitis.At the same time, oxygen inhalation can be guaranteed to increase the oxygen partial pressure, accelerate the patients’ condition, stabilize the patients’ mood and improve the patients’ self-confidence, thereby improving its treatment compliance, better control the disease to improve their quality of life and happiness.