Comparison of efficacy of quadruple regimen with different doses of esomeprazole magnesium in the treatment of helicobacter pylori infection gastritis / 中国基层医药

ABSTRACT

Objective:To compare the efficacy of quadruple regimens with different doses of esomeprazole magnesium in the eradication of helicobacter pylori (Hp) infection gastritis.Methods:From September 2016 to October 2018, the clinical data of 100 patients with Hp infection gastritis in Yuncheng Central Hospital were retrospectively analyzed.All patients received esomeprazole magnesium based quadruple scheme, and according to the different dosage of esomeprazole magnesium, the patients were divided into two groups control group ( n=50) received standard dose of 20 mg, study group ( n=50) received a high dose of 40 mg.The Hp eradication rate, incidence of adverse reactions, the overall curative effect and the recurrence rate were compared between the two groups. Results:The eradication rate of Hp in the study group (98.0%) was higher than that in the control group (84.0%) (χ 2=4.396, P=0.036). The overall effective rate of gastritis in the study group (96.0%) was higher than that in the control group (2.0%) (χ 2=5.005, P=0.025), and the recurrence rate in the study group (0.0%) was lower than that in the control group(12.0%) (χ 2=4.433, P=0.035). The incidence of adverse reactions in the study group (12.0%) was not significantly different from that in the control group (6.0%) (χ 2=0.488, P=0.485). Conclusion:The quadruple regimen with high dose of esomeprazole magnesium has better effect on the eradication of Hp infection gastritis with strong eradication, and it is safe and reliable, so it is recommended to promote.