Effect of interventional therapy via hepatic artery on serum TK1 and CXCL13 levels in patients undergoing microwave ablation of hepatocellular carcinoma / 中国医师杂志

ABSTRACT

Objective:To investigate the effect of interventional therapy via hepatic artery on serum thymidine kinase 1 (TK1) and chemokine ligand 13 (CXCL13) levels in patients undergoing microwave ablation of hepatocellular carcinoma.Methods:A prospective study was conducted in patients with hepatocellular carcinoma treated by microwave ablation in our hospital from December 2014 to January 2019. 140 patients were divided into two groups according to random number method. The control group ( n=70) received microwave ablation for hepatocellular carcinoma. The observation group ( n=70) received hepatic artery perfusion chemotherapy before microwave ablation for hepatocellular carcinoma. The clinical effects of the two groups and the changes of serum TK1 and CXCL13 levels before and after treatment were analyzed. Results:The total effective rate in the observation group was significantly higher than that in the control group (92.9% vs 81.4%; χ 2=2.854, P<0.05). The levels of aspartate aminotransferase (AST) [(40.4±6.69)U/L vs (52.3±8.33)U/L], alanine aminotransferase (ALT) [(40.1±6.96)U/L vs (49.9±6.97)U/L] and total bilirubin (TBIL) [(24.5±3.96)mmol/L vs (35.2±6.31)mmol/L] in the two groups were significantly decreased after treatment ( P<0.05). After treatment, the levels of TK1 [(10.5±3.69)μg/L vs (15.4±4.28)μg/L] and Survivin [(12.6±2.54)μg/L vs (19.2±4.15)μg/L] in the serum were significantly decreased ( P<0.05), while the levels of gene of phosphate and tension homology deleted on chromsome ten (PTEN) [(46.9±5.33)μg/L vs (30.2±4.77)μg/L] were significantly increased ( P<0.05); the levels of CXCL13 [(20.3±4.58)μg/L vs (32.5±5.11)μg/L], CXCL16 [(23.3±4.77)μg/L vs (31.2±5.24)μg/L] and CXC chemokine receptor 5 (CXCR5) [(10.1±2.77)μg/L vs (14.6±2.96)μg/L] were significantly decreased ( P<0.05). After treatment, the changes of the above indexes in the observation group were more obvious than those in the control group ( P<0.05). Conclusions:Interventional therapy via hepatic artery perfusion is more effective for microwave ablation of hepatocellular carcinoma, and can effectively reduce the serum TK1 and CXCL13 levels in patients with hepatocellular carcinoma.