Changes of serum CRP and TRAIL expression in patients with acute viral infection and their clinical value in diagnosis and treatment / 中国医师杂志

ABSTRACT

Objective:To investigate the expression changes of serum C-reactive protein (CRP) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in patients with acute viral infection and the value of clinical diagnosis and treatment.Methods:83 patients with acute viral infection in Hunan Provincial Brain Hospital from March 2018 to June 2019 were selected as the observation group, 81 patients with acute bacterial infection in the same period were selected as the control group A, and 81 healthy people as the control group B for prospective study. On the day of admission or physical examination, peripheral venous blood was drawn; the serum CRP and TRAIL levels were detected. The serum CRP and TRAIL levels of the three groups were compared, and the serum levels of CRP and TRAIL in different treatment groups were analyzed, and the application value of serum CRP and TRAIL in the diagnosis of acute viral infection was analyzed.Results:The serum CRP level of the observation group was lower than that of the control group A, which was higher than that of the control group B ( P<0.05); the serum TRAIL level of the observation group was higher than that of the control group A and B ( P<0.05); the area under the receiver operating characteristic (ROC) curve of the combined diagnosis of serum CRP and TRAIL was 0.921, which was higher than that of the two alone; When the cut-off value of CRP and TRAIL were 5.664 mg/L and 146.82 pg/ml, the combined diagnostic sensitivity was 95.00%, and the specificity was 80.00%; after treatment, the serum CRP and TRAIL levels of the observation group were significantly lower than those before treatment ( P<0.05), and the serum CRP and TRAIL levels of the effective group were lower than those of the ineffective group ( P<0.05). Conclusions:Serum CRP and TRAIL levels have certain value in the identification and efficacy evaluation of patients with acute viral infection. Combined detection can significantly improve the diagnostic value and provide a reliable reference for clinical treatment and prognosis evaluation.