Preliminary study on deoxyribonucleic acid methylation of breast cancer anti-resistance 1, phospho-diesterase 1C, opioid receptor delta 1 and neurexin 1 in gout and hyperuricemia / 中华风湿病学杂志
Chinese Journal of Rheumatology
;
(12): 676-680, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-868247
ABSTRACT
Objective:
To provide a preliminary theoretical basis for gout and hyperuricemia of Deoxyribonucleic acid (DNA) methylation.Methods:
Breast cancer anti-resistance 1(BCAR1), phospho-diesterase 1C (PDE1C), opioid receptor delta 1(OPRD1) and neurexin 1(NRXN1) methylation levels were measured by bisulfite pyrosequencing in 50 gout patients, 30 hyperuricemia patients and 50 matched healthy controls. Comparisons between groups were evaluated by F-test and Nonparametric tests.Results:
Receiver operating characteristic showed that the methylation of PDE1C(pos4, pos5, pos6)(AUC 0.712, 0.772, 0.775; all P values<0.05) had higher accuracy for diagnosis of gout, and OPRD1 pos4 (AUC=0.733, P<0.05) had higher accuracy for hyperuricemia.Conclusion:
DNA methylation may play a role in the development of gout and hyperuricemia, however, further studies are needed.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Rheumatology
Año:
2020
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS