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Screening of radiosensitive lipid metabolites in rat plasma / 中华放射医学与防护杂志
Chinese Journal of Radiological Medicine and Protection ; (12): 420-426, 2020.
Artículo en Chino | WPRIM | ID: wpr-868469
ABSTRACT

Objective:

To screen radiosensitive lipid metabolites in rat plasma and analyze their metabolic pathways in order to provide scientific basis for radiation damage biomarker.

Methods:

The whole body irradiation of 60Co γ rays was performed to rats with different doses of 0, 1, 3 and 5 Gy. The changes of lipids in plasma were detected by untargeted lipidomics method based on liquid chromatography coupled mass spectrometry.

Results:

Twenty plasma lipids were identified as the potential radiosensitive biomarkers at 7 days after irradiation, including 13 over-expressed lipids and 7 down-expressed lipids, where 12 lipids well responded to radiation doses.

Conclusions:

Lipid metabolites in rat plasma are significantly changed after exposure to γ rays, and the metabolic pathways of sphingolipid, glycerophospholipid and glycosylphosphatidylinositol (GPI) are significantly enriched.
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio diagnóstico / Estudio de tamizaje Idioma: Chino Revista: Chinese Journal of Radiological Medicine and Protection Año: 2020 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Tipo de estudio: Estudio diagnóstico / Estudio de tamizaje Idioma: Chino Revista: Chinese Journal of Radiological Medicine and Protection Año: 2020 Tipo del documento: Artículo