Analysis of drug resistance of Pseudomonas aeruginosa in elderly patients with lower respiratory tract infection / 中华老年医学杂志

ABSTRACT

Objective:To investigate the drug resistance of Pseudomonas aeruginosa to common antibiotics in elderly patients with lower respiratory tract infection.Methods:110 patients with lower respiratory tract infection in our hospital were enrolled in this study from February 2018 to May 2019.The sputum specimens were cultured in vitro, and Pseudomonas aeruginosa was tested for in-vitro susceptibility.The results of drug susceptibility test were analyzed.Results:A total of 60 strains of Pseudomonas aeruginosa were isolated from the 110 elderly patients, with a detection rate of 54.6%.The resistance rate of 60 strains of Pseudomonas aeruginosa to gentamicin was as high as 63.3%, followed by tobramycin(46.7 %), piperacillin( 41.7%), ciprofloxacin( 38.3%), etc.The resistance rate to aztreonam was the lowest(13.3%). The in-vitro susceptibility test was conducted in only 15 patients infected with β-lactamase-producing Pseudomonas aeruginosa.And this test results showed that the drug resistance rates to gentamicin, tobramycin, piperacillin, ciprofloxacin, piperacillin/tazobactam were 100.0%, followed by cefepime, amikacin and cefoperazone, and the resistance rate to aztreonam was the lowest, only 20.0%.Conclusions:Pseudomonas aeruginosa reveals a high resistance to common antibiotics such as gentamicin, piperacillin and cefoperazone.While aztreonam can still exhibit an obvious anti-bacterial activity against Pseudomonas aeruginosa.And it can be used as an alternative medicine in the clinical treatment of lower respiratory tract infection caused by Pseudomonas aeruginosa in elderly patients.