Research progress on the correlation between chronic obstructive pulmonary disease and sarcopenia / 中华老年医学杂志

ABSTRACT

As the population ages, the incidences of age-related diseases such as chronic obstructive pulmonary disease(COPD)and sarcopenia are on the rise.A growing number of studies have found that there is a close relationship between COPD and sarcopenia.Quadriceps weakness, atrophy, and fiber type conversion of skeletal muscles are common in patients with COPD.At the same time, respiratory muscles also have adaptive changes, resulting in limited mobility, decreased quality of life and increased hospitalization rates and mortality.However, mechanisms underlying the interaction between COPD and sarcopenia have not been fully illuminated.Moreover, clinicians usually fail to make early identification and start intervention for COPD-related skeletal muscle dysfunction.This article reviews progress on the epidemiology, mechanisms linking the two conditions and treatment of COPD-related sarcopenia as a reference for clinical practice.