Effect of gender factor on sufentanil-induced inhibition of responses to endotracheal intubation when combined with dexmedetomidine / 中华麻醉学杂志

ABSTRACT

Objective:To evaluate the effect of gender factor on sufentanil-induced inhibition of responses to endotracheal intubation when combined with dexmedetomidine.Methods:American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients, aged 18-64 yr, with body mass index <30 kg/m 2, undergoing elective surgery under general anesthesia requiring tracheal intubation, were divided into 2 groups according to gender male group (group M) and female group (group F). Dexmedetomidine 0.4 μg/kg was intravenously infused over 5 min, and 10 min later propofol 3 μg/ml and sufentanil were given by target-controlled infusion.In the two groups, the initial target concentration of sufentanil was set at 0.35 ng/ml in the first case, the target concentration of sufentanil in the next case was determined according to whether responses to endotracheal intubation occurred, and the ratio between the two consecutive target concentrations was 1.2.The median effective concentration (EC 50) and 95% confidence interval (CI) of sufentanil inhibiting responses to endotracheal intubation were determined by Dixon′s up and down sequential trial. Results:There were 26 cases in group M and 28 cases in group F. The EC 50 (95% CI) of sufentanil was 0.264 0 (0.240 9-0.289 3) ng/ml in group M. The EC 50 (95% CI) of sufentanil was 0.158 9 (0.138 2-0.182 6) ng/ml in group F. The EC 50 of sufentanil was significantly lower in group F than in group M ( P<0.05). Conclusion:Gender-related differences exist in sufentanil-induced inhibition of responses to endotracheal intubation when combined with dexmedetomidine.