Carbamazepine-induced toxic epidermal necrolysis in a patient with HLA-A*31:01 allele / 中华皮肤科杂志

ABSTRACT

Objective:To detect susceptibility genes for toxic epidermal necrolysis (TEN) caused by carbamazepine in a patient.Methods:Clinical data and peripheral blood samples were collected from a patient with carbamazepine-induced TEN. DNA was extracted from the peripheral blood samples, fluorescence in situ hybridization was performed to detect susceptibility gene loci for carbamazepine-induced TEN, including HLA-A*31:01 (rs1633021), HLA-B*58:01 (rs3095318), HLA-B*15:02 (rs3909184) and HLA-B*15:02 (rs2844682) . Results:The 40-year-old female patient of Han nationality presented with perioral erythema and blisters for 7 days, which had spread all over the body for 4 days. The patient had been treated with carbamazepine for 1 month before the occurrence of skin lesions. Genetic testing showed that the patient was negative for HLA-B*15:02 allele, but positive for HLA-A*31:01 allele.Conclusion:The Chinese patient of Han nationality with carbamazepine-induced TEN was positive for HLA-A*31:01 allele.