Analysis of the incidence and treatment of lung cancer after lung transplantation / 中华器官移植杂志

ABSTRACT

Objective:To explore the incidence and treatment of lung cancer after lung transplantation.Methods:Between January 2003 and July 2016, 80 patients were retrospectively reviewed after lung transplantation. And the incidence, treatment and prognosis of lung cancer were analyzed after lung transplantation.Results:Twelve cases (15%) of malignancies occurred after lung transplantation, including lung cancer ( n=10, 12.5%), renal carcinoma ( n=1, 1.25%) and larynx cancer ( n=1, 1.25%). One lung cancer patient became lost to follow-ups. Among 9 other cases, 5 patients of stage I lung cancer had a median survival of >24 months while another 4 patients with stage II/III lung cancer had a median survival of 2.5(2-5) months. All tumors occurred at the preserved side. Pathological types included squamous cell carcinoma, adenocarcinoma, adenosquamous cell carcinoma and small cell lung cancer. Age(61.8±6.6 vs. 54.0±11.0 years, P=0.03) and smoking (20.4% vs. 2.7%, P=0.02)were two important risk factors for lung cancer. The differences were statistically significant. Conclusions:Lung cancer is a major late complication after lung transplantation. Age and smoking are two important risk factors for lung cancer. The pathological types of lung cancer are diverse and the overall prognosis is poor.