Recent progress in vaccine development against chikungunya virus infection / 中华微生物学和免疫学杂志

ABSTRACT

Chikungunya virus(CHIKV)is a member of the genus Alphavirus, family Togaviridae and transmitted to humans by Aedes aegypti and Aedes albopictus. It mainly causes Chikungunya fever (CHIKF) with high fever, rash and multiple arthritis/joint pain as the main clinical symptoms, and is a major public health threat of global concern. There is still no vaccine or effective antiviral drug against CHIKV. This review briefly summarized the genomic and epidemiological characteristics of CHIKV, features of immune response to major CHIKV antigens and latest progress in vaccine development.