Progress of relationship between autophagy and hepatocellular carcinoma / 肿瘤研究与临床

ABSTRACT

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with quick disease progression and poor prognosis. The pathogenesis is extremely complex, involving genetic mutations, abnormal activation of signal pathways, and epigenetic changes. Autophagy is a basic physiological phenomenon of maintaining internal environment stability and promoting cell survival when cell stress occurs, which plays an important role in the occurrence, development and prognosis of various tumors including HCC. Autophagy can participate in the formation and progress of HCC through the above molecular mechanisms. This paper reviews the progress of relationship between autophagy and HCC.