The prognosis of hepatitis E superinfection in hospitalized chronic hepatitis B patients in China: A systematic review and Meta-analysis / 中华疾病控制杂志

ABSTRACT

@#Objective To evaluate the prevalence and prognosis of hepatitis E virus ( HEV) su- perinfection in patients with chronic hepatitis B ( CHB) ． Methods Electronic databases of Pubmed， CNKI，and Wanfang were searched，and references of the relevant articles for literatures associated with HEV superinfection in CHB patients in China published during 2008－2019 were screened． Studies which met the inclusion and exclusion criterias were selected and related data were pooled for analysis． The Ｒ 3. 5. 2 and Ｒevman 5. 3 were used to measure heterogeneity with the I2 statistic and pooled incidence and odds ratio ( OＲ) ． Ｒesults 28 literatures were eligible for inclusion． The results showed the rate of HEV superinfection in hospitalized CHB ( CHB-HEV) patients was 13. 6% ( 95%CI 12. 5% －14. 9%) ． The pooled incidence of liver failure in CHB-HEV patients was 34. 7% ( 95%CI 29. 6%－40. 1%) ，which was higher than CHB patients ( OＲ= 10. 9，95%CI 6. 8－17. 4) ，CHB patients superinfected with hepatitis A virus ( CHB-HAV) ( OＲ= 3. 8，95%CI 2. 4－6. 2) ，and hepatitis E patients ( OＲ= 5. 1，95%CI 3. 8－ 6. 8) ． The pooled mortality of CHB-HEV patients was 13. 8% ( 95%CI 10. 3－17. 8) ，which was higher than CHB patients ( OＲ = 8. 5，95%CI 4. 0－18. 3) ，CHB-HAV patients ( OＲ = 14. 4，95%CI 4. 8－ 42. 9) ，and hepatitis E patients ( OＲ= 4. 4，95%CI 3. 0－6. 4) ． Conclusion In China，HEV sueperinfection on chronic hepatitis B patients are common，and is an important cause of liver failure and death．