Review on the association of CAG short tandem repeats of androgen receptor gene with tumorigenesis and prognosis / 中华疾病控制杂志
Chinese Journal of Disease Control & Prevention
;
(12): 359-364, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-873512
ABSTRACT
@#Abnormal expression of androgen receptor ( AR) and AR-mediated signaling pathways are closely related to the occurrence,outcome,and prognosis of various human disease,and to some ex- tent,AR lead to gender differences in these diseases. However,the specific mechanism is still unclear. CAG short tandem repeat ( STR) sequence in exon 1 of AR gene negatively correlates with the transcriptional regulation activity,affects the synthesis and biological function of the target proteins,and plays an important role in the development and prognosis of various tumors,such as prostate cancer,breast cancer,bladder cancer,liver cancer,and endometrial cancer. In this review,we summarized the current studies on the association between AR gene CAG STR and the common tumors,in order to provide clues for further exploring the mechanism of AR-related tumors with high incidence and gender differences,and screening populations with high risk for the corresponding tumors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio pronóstico
Idioma:
Chino
Revista:
Chinese Journal of Disease Control & Prevention
Año:
2020
Tipo del documento:
Artículo
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