A case of gonadoblastoma in patient with mixed gonadal dysgenesis / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 1204-1208, 2002.
Article
en Ko
| WPRIM
| ID: wpr-87506
Biblioteca responsable:
WPRO
ABSTRACT
Gonadoblastoma occurs almost always in association with a Y chromosome cell line, and developes in one third of patients with Mixed gonadal dysgenesis. Removing of gonads of intersex patients with the Y chromosome is very important because of the strong association of the genesis of tumor in dysgenetic gonads with the presence of a Y chromosome. But it is always possible that an XY cell line could be missed, or that a fragment from Y chromosome could have been translocated and not discovered by chromosomal analysis. PCR with Y specific probe or Southern blotting would reveal the presence of a Y or a translocated fragment. We experienced an 18-year-old woman represent with primary amenorrhea who had 45,X/46,X,+mar. Y-specific PCR revealed that the marker chromosome was drived from Y chromosome. After both gonadectomy and clitorial recession, we found the gonadoblastoma in dysgenetic testis. So we report it with brief review of literatures.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Testículo
/
Cromosoma Y
/
Línea Celular
/
Southern Blotting
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Reacción en Cadena de la Polimerasa
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Gonadoblastoma
/
Amenorrea
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Disgenesia Gonadal Mixta
/
Gónadas
Límite:
Adolescent
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Female
/
Humans
Idioma:
Ko
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2002
Tipo del documento:
Article