Clinical and Histopathologic Study of Lichen Nitidus-Like Papular Eruptions; Eruptive Idiopathic Papulosis / 대한피부과학회지

ABSTRACT

Background@#A large number of patients present with multiple papular skin lesions at the outpatient department of dermatology. In practice, however, the clinical presentation and skin histology has often been difficult to classify as a specific disease group. @*Objective@#The purpose of this study was to analyze the clinical and histopathologic characteristics in patients at a single center with papular eruptions that looked clinically similar to lichen nitidus. Finally, we propose a new disease category with the series of characteristics we found. @*Methods@#We retrospectively reviewed and analyzed the medical records, clinical photographs, and histopathologic slides of 22 patients who underwent skin biopsies for the diagnosis of lichen nitidus-like papular lesions. @*Results@#There were 16 men (72.7%) and 6 women (27.3%) included with a mean age at onset of 13.3 years. There were 17 children (77.3%) and 5 adults (22.7%). Eleven patients (50%) had pruritic symptoms. Fifteen patients (68.2%) had generalized eruptions. The localized eruptions predominantly involved the upper extremity (31.0%), especially the dorsum of the hands (14.1%). The most frequent histopathologic changes were superficial perivascular inflammatory cell infiltration (100%) and epidermal acanthosis (95%). @*Conclusion@#Our study was an overall review of flat or dome-shaped papular eruptions. The data are expected to contribute to the identification of the characteristics of this cutaneous disease that has been difficult to categorize.