Circulating tumor DNA in lung cancer: real-time monitoring of disease evolution and treatment response / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2476-2485, 2020.
Artículo
en Inglés
| WPRIM
| ID: wpr-877855
ABSTRACT
Lung cancer is one of the leading causes of all cancer-related deaths. Circulating tumor DNA (ctDNA) is released from apoptotic and necrotic tumor cells. Several sensitive techniques have been invented and adapted to quantify ctDNA genomic alterations. Applications of ctDNA in lung cancer include early diagnosis and detection, prognosis prediction, detecting mutations and structural alterations, minimal residual disease, tumor mutational burden, and tumor evolution tracking. Compared to surgical biopsy and radiographic imaging, the advantages of ctDNA are that it is a non-invasive procedure, allows real-time monitoring, and has relatively high sensitivity and specificity. Given the massive research on non-small cell lung cancer, attention should be paid to small cell lung cancer.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Biomarcadores de Tumor
/
Carcinoma de Pulmón de Células no Pequeñas
/
ADN Tumoral Circulante
/
Neoplasias Pulmonares
/
Mutación
Tipo de estudio:
Estudio de tamizaje
Límite:
Humanos
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2020
Tipo del documento:
Artículo
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