Progress of epithelial-mesenchymal transition in respiratory system and the modulatory mechanism of cell adhesion / 生理学报
Acta Physiologica Sinica
; (6): 605-616, 2020.
Article
en Zh
| WPRIM
| ID: wpr-878206
Biblioteca responsable:
WPRO
ABSTRACT
Epithelial-mesenchymal transition (EMT) plays an important role in the development and pathogenesis of respiratory system. Epithelial cells are characterized by well-developed, intercellular contacts, whereas EMT triggers the sequential destabilization of cell-cell adhesive junctions. The dynamic remodeling of the epithelial cell adhesion molecules is important for maintaining the integrity and normal function of epithelium. This paper reviews the research progress of EMT in lung development, lung injury repair and chronic lung diseases, and summarizes the effect of cell junctions and cell adhesion molecules on EMT molecular events.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Sistema Respiratorio
/
Moléculas de Adhesión Celular
/
Adhesión Celular
/
Células Epiteliales
/
Transición Epitelial-Mesenquimal
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Año:
2020
Tipo del documento:
Article