New advances in oxygen sensing and adaptive mechanism / 生理学报
Acta Physiologica Sinica
;
(6): 660-666, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-878211
ABSTRACT
Under the hypoxic condition, organs or cells trigger a series of reactions or responses to adapt to the physiological requirement. These responses involve a complex regulation at different levels from organs, in particular the kidney (producing erythropoietin), to cells throughout the body. Actually, the responses to hypoxia from adaption to injury largely depend on the degree and time of hypoxia. In the past two decades, with the discovery of hypoxia-inducible factor (HIF), the mechanisms of erythropoiesis regulation were elucidated gradually, which has provided a novel therapeutic strategy for hypoxia-related diseases, especially renal anemia. In this review we focus on the latest advances in oxygen sensing and adaptive mechanism.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Oxígeno
/
Anemia
/
Riñón
/
Enfermedades Renales
/
Hipoxia
Límite:
Humanos
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2020
Tipo del documento:
Artículo
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