Positive inotropic effect of phosphodiesterase type 9 inhibitor PF-04449613 in rats and its underlying mechanism / 生理学报
Acta Physiologica Sinica
;
(6): 275-285, 2021.
Artículo
en Chino
| WPRIM
| ID: wpr-878256
ABSTRACT
This study aimed to explore the positive inotropic effect of phosphodiesterase type 9 (PDE9) inhibitor PF-04449613 in ratsand its cellular and molecular mechanisms. The heart pressure-volume loop (P-V loop) analysis was used to detect the effects of PF-04449613 on rat left ventricular pressure-volume relationship, aortic pressures and peripheral vessel resistance in healthy rats. The Langendorff perfusion of isolated rat heart was used to explore the effects of PF-04449613 on heart contractility. The cardiomyocyte sarcoplasmic reticulum (SR) Ca
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Inhibidores de Fosfodiesterasa
/
Retículo Sarcoplasmático
/
Calcio
/
Hidrolasas Diéster Fosfóricas
/
Canal Liberador de Calcio Receptor de Rianodina
/
Miocitos Cardíacos
/
Contracción Miocárdica
Límite:
Animales
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2021
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS