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Research progress of the role of IGF-1 in metabolic diseases and the effect of exercise intervention / 生理学报
Acta Physiologica Sinica ; (6): 342-352, 2021.
Artículo en Chino | WPRIM | ID: wpr-878262
ABSTRACT
Insulin-like growth factor-1 (IGF-1) is a peptide with a similar molecular structure to insulin. IGF-1 plays a key role in tissue growth and development, as well as cell metabolism, proliferation, differentiation and apoptosis. Liver is the main source of IGF-1, with the production of IGF-1 up to 75% of the total in the whole body, while the remaining 25% are secreted by skeletal muscles, heart, kidney, spleen and other organs. Target organs of IGF-1 include heart, blood vessels, liver, bone and skeletal muscles. It has been well documented that IGF-1 plays an important role in the prevention and treatment of metabolic diseases. Different types of exercise have different effects on IGF-1 expression with organ differences. In this article, we reviewed the preventive and therapeutic effects of IGF-1 on metabolic diseases and IGF-1-mediated exercise-induced benefits.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Factor I del Crecimiento Similar a la Insulina / Músculo Esquelético / Terapia por Ejercicio / Hígado / Enfermedades Metabólicas Límite: Humanos Idioma: Chino Revista: Acta Physiologica Sinica Año: 2021 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Factor I del Crecimiento Similar a la Insulina / Músculo Esquelético / Terapia por Ejercicio / Hígado / Enfermedades Metabólicas Límite: Humanos Idioma: Chino Revista: Acta Physiologica Sinica Año: 2021 Tipo del documento: Artículo