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Research progress of Pictet-Spenglerases / 生物工程学报
Chinese Journal of Biotechnology ; (12): 2001-2016, 2020.
Artículo en Chino | WPRIM | ID: wpr-878461
ABSTRACT
Pictet-Spenglerases (P-Sases) catalyze the Pictet-Spengler (P-S) reactions and exhibit high stereoselectivity and regioselectivity under mild conditions. The typical P-S reaction refers to the condensation and recyclization of β-arylethylamine with aldehyde or ketone under acidic conditions to form tetrahydroisoquinoline and β-carboline alkaloid derivatives. The related enzymatic products of P-Sases are the backbones of various bioactive compounds, including clinical drugs morphine, noscapine, quinine, berberine, ajmaline, morphine. Furthermore, the activity of P-Sases in stereoselective and regioselective catalysis is also valuable for chemoenzymatic synthesis. Therefore, this review summarizes the research progress in the discovery, functional identification, biological characteristics and catalytic applications of P-Sases, which provide the useful theoretical reference in future P-Sases research and development.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Investigación / Catálisis / Tetrahidroisoquinolinas / Alcaloides / Enzimas Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Chinese Journal of Biotechnology Año: 2020 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Investigación / Catálisis / Tetrahidroisoquinolinas / Alcaloides / Enzimas Tipo de estudio: Estudio pronóstico Idioma: Chino Revista: Chinese Journal of Biotechnology Año: 2020 Tipo del documento: Artículo