Application of glycan microarrays in cancer research / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 2313-2326, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-878488
ABSTRACT
Glycosylation is one of the common post-translational modifications of proteins to regulate the ability of tumor invasion, metastasis and tumor heterogeneity by interacting with glycan-binding proteins such as lectins and antibodies. Glycan microarray can be constructed by chemical synthesis, chemical-enzyme synthesis or natural glycan releasing. Glycan microarray is an essential analytical tool to discover the interaction between glycan and its binding proteins. Here we summarize the standard techniques to construct glycan microarray for the application in cancer vaccine, monoclonal antibody and diagnostic markers.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polisacáridos
/
Glicosilación
/
Análisis por Micromatrices
/
Lectinas
/
Anticuerpos Monoclonales
/
Neoplasias
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2020
Tipo del documento:
Artículo
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